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software-freedom.info is a search engine focus on software reviews. Our main review focus on Software Review, Windows Software, Mac Software, Linux Software, Mobile Software, Game Software. We provide reviews of software programs/games for Windows.Numerical model of disease progression in chronic atrophic gastritis and the role of pepsinogens in the stomach.

We present a mathematical model describing the progression of atrophic gastritis in the stomach. Using a previously validated model that characterizes the kinetics of the reduction of the acid-suppressive H+,K+ATPase (apical pump) in the parietal cell, we have extended the model to describe in more detail the effect of gastric ulcers and chronic atrophic gastritis on the production of the mucus-secreting MUC5AC- and pepsinogen-expressing parietal cells in the corpus and antrum of the stomach. We present results from simulations of the steady state of our model describing the relation of the luminal concentration of gastric fluid and the level of gastric acidity. In the presence of chronic atrophic gastritis, we find that the total gastric pepsinogen concentration is reduced due to loss of parietal cells expressing pepsinogens. However, at physiological levels of gastric acidity (pH ∼ 2.0), the luminal pepsinogen concentration is higher than the pepsinogen concentration in the gastric fluid, suggesting that loss of pepsinogen-expressing parietal cells is a relevant source of luminal pepsinogens. Furthermore, we find that pepsinogen-expressing parietal cells in the corpus are more susceptible to gastric ulcers than those in the antrum.If this is your first visit, be sure to

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